Obesity-induced dysregulation of a unique subset of Tregs promotes skin inflammation

Abstract Obesity is associated with increased skin inflammation and a major risk factor for psoriasis, raising the question of how obesity disrupts regulatory mechanisms that keep in check at steady state. We found was enriched unique subset CD4 +Foxp3 +regulatory T cells (Tregs), which critical to limit IL-17A-mediated psoriatic inflammation. Diet-induced obesity, however, resulted significant reduction this Tregs corresponding loss control over Mechanistically, specific Treg population preferentially took up elevated levels long-chain saturated fatty acids during led cellular lipotoxicity mitochondrial dysfunction. Harnessing anti-inflammatory property could have therapeutic potential obesity-associated inflammatory diseases. Supported from grants NIH/NIDDK (1R01DK128061), National Psoriasis Foundation, Emory University Research Committee (URC).